ca. 1424

[Possible/Probable] “Prohibition of Sexual Relations between Jews and Christians” [Venice] 

Commentary from other sources:
1) “In 1424 another decree established that sexual intercourse between Jewish men and Christian women was a criminal offense: the culprit [Jew] had to pay a fine and serve 6 months in prison if the partner was a lower class woman and 12 months in case of a noblewoman.”

http://veniceapartmentrentals.com/jewish-ghetto